I hit a really rough patch of road on trip pulling #7000 LB loaded enclosed trailer and now truck has high speed whine. Sounds like it is coming from rear end. I have crawled under and jacked up each wheel to see if I can find anything obvious but not nothing. I then attempted to jack up rear and run truck (4WD diesel Colorado, 45k miles) but truck would not go above idle so could not replicate speed and sound. I am thinking computer does not like speed mismatch or something, it is in 2WD mode. This does not make sense to me as I can spin the tires when on dirt. Any way internet search leads me to believe it is the rear end ring and pinion. The question is, can the truck make it home 2500 miles pulling the trailer. The trailer will be unloaded going home.