Most tuners that offer delete tuning, at least MotorOps, All-In Truck Performance and probably Dans Diesel and OZ Tuner (not for sure though on those two) will give you more than just 1 tune. The delete part is just built into the programming of those manufacturers products to do away with the emissions system. It will turn it off, and it's up to you if you want to leave it on the truck or take it off. Leaving it on there will probably help you, but all of the parts that are restricting things are still in place. Like I said though, all of those manufacturers offer more than 1 tune, although they do offer a single tune option as well.
Single tune; you just choose what you want like performance, tow, fuel economy, whatever.
Multi-Tune is available by either plugging the Auto Cal unit into your diagnostic port and changing the tunes on there as you wish, which takes about 10 minutes to change, or they also have where you can add a DSP4 switch (MotorOps has this for sure, and I believe others have it but I can't say for sure who) which allows you to switch tune on the go while driving down the road. Most manufacturers have 4-5 tunes that will come with a multi-tune auto cal: improved stock, tow, sport-economy and performance.
Here is the link to the MotorOps unit I mentioned. It is in Canadian dollars, but you can do a CAD to USD conversion to figure out the price and they do ship to the US btw. http://motorops.ca/tuning/duramax/2-8l-duramax-canyon-colorado-auto-cal.html